Reactome | Reduction of presqualene diphosphate to form squalene

Reduction of presqualene diphosphate to form squalene

Stable Identifier

R-HSA-191402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

presqualene diphosphate + NADPH + H(+) => squalene + diphosphate + NADP(+)

ReviewStatus

5/5

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Reduction of presqualene diphosphate to form squalene

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In the second step of squalene formation from farnesyl diphosphate (FAPP), FDFT (Farnesyl-diphosphate farnesyltransferase) catalyzes the reduction of presqualene diphosphate (PSQPP) to squalene (SQNE) (Pandit et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10896663	Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. Pandit, J, Danley, DE, Schulte, GK, Mazzalupo, S, Pauly, TA, Hayward, CM, Hamanaka, ES, Thompson, JF, Harwood HJ, Jr	J Biol Chem	2000