Reactome | NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP

NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP

Stable Identifier

R-HSA-2395872

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2-hydroxy-ATP + H2O => 2-hydroxy-AMP + PPi

ReviewStatus

5/5

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NUDT1 (MTH1) catalyzes the reaction of 2-oxo-ATP and water to form 2-oxo-AMP and PPi (pyrophosphate). Four NUDT1 proteins have been identified, encoded by a single gene with alternative start codons (Oda et al. 1999). The shortest of these, NUDT1 p18, has been shown to catalyze hydrolysis of 2-oxo-ATP (Fujikawa et al. 2001). The active enzyme is a monomer associated with a magnesium ion (Mishima et al. 2004). The longer isoforms all consist of the p18 polypeptide with aminoterminal extensions and are presumed to be active as well, but have not been experimentally characterized. The p18 isoform is predominantly cytosolic (Kang et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
15133035	Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates Mishima, M, Sakai, Y, Itoh, N, Kamiya, H, Furuichi, M, Takahashi, M, Yamagata, Y, Iwai, S, Nakabeppu, Y, Shirakawa, M	J. Biol. Chem.	2004
11139615	Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP Fujikawa, K, Kamiya, H, Yakushiji, H, Nakabeppu, Y, Kasai, H	Nucleic Acids Res.	2001
7782328	Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria Kang, D, Nishida, J, Iyama, A, Nakabeppu, Y, Furuichi, M, Fujiwara, T, Sekiguchi, M, Takeshige, K	J. Biol. Chem.	1995