Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)

Stable Identifier
R-HSA-9694733
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)
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SARS-CoV-2 transcripts are polyadenylated (Ravindra et al. 2020, Kim et al. 2020), similar to their SARS-CoV-1 counterparts. SARS-CoV-2 subgenomic RNAs (sgRNAs) carry poly(A) tails of the meadian lenght of 47 nucleotides. The poly(A) tails of sgRNAs of SARS-CoV-2 are shorter than the poly(A) tails of the full-length SARS-CoV-2 genomic RNA (Kim et al. 2020).

SARS-CoV-1 plus strand sgRNAs share a 3'UTR with the plus strand genomic RNA, and as this 3'UTR possesses a polyadenylation signal, they undergo polyadenylation by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).
Literature References
PubMed ID Title Journal Year
32330414 The Architecture of SARS-CoV-2 Transcriptome

Kim, D, Lee, JY, Yang, JS, Kim, JW, Kim, VN, Chang, H

Cell 2020
32511382 Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells

Ravindra, NG, Alfajaro, MM, Gasque, V, Wei, J, Filler, RB, Huston, NC, Wan, H, Szigeti-Buck, K, Wang, B, Montgomery, RR, Eisenbarth, SC, Williams, A, Pyle, AM, Iwasaki, A, Horvath, TL, Foxman, EF, van Dijk, D, Wilen, CB

bioRxiv 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Orlic-Milacic, M  (2020-08-12)
Senff-Ribeiro, A  (2020-08-12)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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