Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)

Stable Identifier
R-HSA-9694733
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SARS-CoV-2 transcripts are polyadenylated (Ravindra et al. 2020, Kim et al. 2020), similar to their SARS-CoV-1 counterparts. SARS-CoV-2 subgenomic RNAs (sgRNAs) carry poly(A) tails of the meadian lenght of 47 nucleotides. The poly(A) tails of sgRNAs of SARS-CoV-2 are shorter than the poly(A) tails of the full-length SARS-CoV-2 genomic RNA (Kim et al. 2020).

SARS-CoV-1 plus strand sgRNAs share a 3'UTR with the plus strand genomic RNA, and as this 3'UTR possesses a polyadenylation signal, they undergo polyadenylation by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).
Literature References
PubMed ID Title Journal Year
32330414 The Architecture of SARS-CoV-2 Transcriptome

Kim, JW, Kim, D, Lee, JY, Yang, JS, Chang, H, Kim, VN

Cell 2020
32511382 Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells

Iwasaki, A, Wang, B, Alfajaro, MM, van Dijk, D, Wan, H, Wei, J, Montgomery, RR, Foxman, EF, Horvath, TL, Ravindra, NG, Wilen, CB, Szigeti-Buck, K, Gasque, V, Huston, NC, Pyle, AM, Williams, A, Eisenbarth, SC, Filler, RB

bioRxiv 2020
Participants
Participates
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
Cite Us!