DHCA is conjugated with Coenzyme A (SLC27A5 BACS)

Stable Identifier
R-HSA-193407
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
ReviewStatus
5/5
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DHCA is conjugated with Coenzyme A (SLC27A5 BACS)
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DHCA (25(R) 3alpha,7alpha-dihydroxy-5beta-cholestanoate) , coenzyme A, and ATP react to form the CoA conjugate of 25(R) DHCA, AMP, and pyrophosphate. This cytosolic reaction is catalyzed by SLC27A5 (BACS). SLC27A2 (VLCS) also catalyzes this reaction; the relative contributions of the two enzymes to de novo bile acid synthesis in vivo are not certain (Mihalik et al. 2002).
Literature References
PubMed ID Title Journal Year
10479480 Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein

Steinberg, SJ, Wang, SJ, McGuinness, MC, Watkins, PA

Mol Genet Metab 1999
11980911 Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling

Mihalik, SJ, Steinberg, SJ, Pei, Z, Park, J, Kim, DG, Heinzer, AK, Dacremont, G, Wanders, RJA, Cuebas, DA, Smith, KD, Watkins, PA

J Biol Chem 2002
10749848 The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase

Steinberg, SJ, Mihalik, SJ, Kim, DG, Cuebas, DA, Watkins, PA

J Biol Chem 2000
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Output
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as an event of
Catalyst Activity

long-chain fatty acid-CoA ligase activity of SLC27A5 [endoplasmic reticulum membrane]

Physical Entity
SLC27A5 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
long-chain fatty acid-CoA ligase activity (GO:0004467)
Orthologous Events
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
Authored
Jassal, B  (2007-01-19)
Reviewed
D'Eustachio, P  (2007-04-30)
Created
D'Eustachio, P  (2007-02-19)
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