ISGylation of PKR

Stable Identifier
R-HSA-9833973
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ISGylation of PKR
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PKR (EIF2AK2) is modified by ISG15 ligase complex on lysine residues 69 and 159, which activates PKR by dimerization and autophosphorylation, leading to down-regulation of protein translation without the necessity of RNA binding to PKR (Okomura et al, 2013).
Literature References
PubMed ID Title Journal Year
23229543 Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation

Okumura, AJ, Okumura, F, Kamura, T, Hatakeyama, S, Zhang, DE, Uematsu, K

J Biol Chem 2013
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Catalyst Activity

ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

Physical Entity
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
ISGylation of PKR (Bos taurus)
ISGylation of PKR (Caenorhabditis elegans)
ISGylation of PKR (Drosophila melanogaster)
ISGylation of PKR (Mus musculus)
ISGylation of PKR (Rattus norvegicus)
ISGylation of PKR (Sus scrofa)
Authored
Stephan, R  (2023-05-05)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-05)
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