acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

Stable Identifier
R-HSA-71735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Luong et al. 2000).

Literature References
PubMed ID Title Journal Year
10843999 Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.

Luong, A, Hannah, VC, Goldstein, JL

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetate-CoA ligase activity of ACSS2 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Cite Us!