acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]

Stable Identifier
R-HSA-71735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
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Cytosolic ACSS2 (acetyl-coenzyme A synthetase) catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Luong et al. 2000).

Literature References
PubMed ID Title Journal Year
10843999 Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.

Goldstein, JL, Luong, A, Hannah, VC

J Biol Chem 2000
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Catalyst Activity

acetate-CoA ligase activity of ACSS2 [cytosol]

Physical Entity
ACSS2 [cytosol] (Homo sapiens)
Activity
acetate-CoA ligase activity (GO:0003987)
Orthologous Events
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Danio rerio)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Drosophila melanogaster)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Gallus gallus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-05-19)
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