Reactome | FLAD1 phosphorylates FMN

FLAD1 phosphorylates FMN

Stable Identifier

R-HSA-196929

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + FMN + H(+) => diphosphate + FAD, FMN is futher phosphorylated to FAD

ReviewStatus

5/5

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FMN can be phosphorylated and adenylated to produce the second cofactor from riboflavin origins, flavin adenine dinucleotide (FAD). The enzyme responsible , FMN adenylyltransferase (FLAD1 aka FAD synthase), is cytosolic and transfers a phosphate and an adenyl group from ATP to form FAD.

Literature References

PubMed ID	Title	Journal	Year
16643857	Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase Brizio, C, Galluccio, M, Wait, R, Torchetti, EM, Bafunno, V, Accardi, R, Gianazza, E, Indiveri, C, Barile, M	Biochem Biophys Res Commun	2006