TetraHCA (25(R) 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate), coenzyme A, and ATP react to form the CoA conjugate of 25(R) TetraHCA, AMP, pyrophosphate and water. This cytosolic reaction is catalyzed by SLC27A2 (VLCS). SLC27A5 (BACS) also catalyzes this reaction; the relative contributions of the two enzymes to de novo bile acid synthesis in vivo are not certain (Mihalik et al. 2002).
McGuinness, MC, Watkins, PA, Wang, SJ, Steinberg, SJ
Mihalik, SJ, Smith, KD, Heinzer, AK, Watkins, PA, Wanders, RJA, Dacremont, G, Park, J, Pei, Z, Kim, DG, Steinberg, SJ, Cuebas, DA
Mihalik, SJ, Watkins, PA, Kim, DG, Steinberg, SJ, Cuebas, DA
long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]
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