TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

Stable Identifier
R-HSA-193727
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
TetraHCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
ReviewStatus
5/5
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TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TetraHCA (25(R) 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate), coenzyme A, and ATP react to form the CoA conjugate of 25(R) TetraHCA, AMP, pyrophosphate and water. This cytosolic reaction is catalyzed by SLC27A2 (VLCS). SLC27A5 (BACS) also catalyzes this reaction; the relative contributions of the two enzymes to de novo bile acid synthesis in vivo are not certain (Mihalik et al. 2002).
Literature References
PubMed ID Title Journal Year
10479480 Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein

McGuinness, MC, Watkins, PA, Wang, SJ, Steinberg, SJ

Mol Genet Metab 1999
11980911 Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling

Mihalik, SJ, Smith, KD, Heinzer, AK, Watkins, PA, Wanders, RJA, Dacremont, G, Park, J, Pei, Z, Kim, DG, Steinberg, SJ, Cuebas, DA

J Biol Chem 2002
10749848 The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase

Mihalik, SJ, Watkins, PA, Kim, DG, Steinberg, SJ, Cuebas, DA

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]

Physical Entity
SLC27A2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
long-chain fatty acid-CoA ligase activity (GO:0004467)
Orthologous Events
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
Authored
D'Eustachio, P  (2007-02-24)
Reviewed
D'Eustachio, P  (2007-04-30)
Created
D'Eustachio, P  (2007-02-24)
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