Reactome | UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose

UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose

Stable Identifier

R-HSA-70286

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

alpha-D-glucose 1-phosphate + UTP + H(+) => UDP-alpha-D-glucose + diphosphate

ReviewStatus

5/5

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UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose

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Cytosolic UDP-glucose pyrophosphorylase 2 (UGP2) catalyzes the reaction of UTP and glucose 1-phosphate to form UDP glucose and pyrophosphate (Knop and Hansen 1970; Duggleby et al. 1996). UGP2 is inferred to occur in the cell as a homooctamer from studies of its bovine homologue (Levine et al. 1969).

Literature References

PubMed ID	Title	Journal	Year
8631325	Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli. Duggleby, RG, Peng, HL, Chao, YC, Chang, HY, Huang, JG	Eur J Biochem	1996
5427280	Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization and properties of the enzyme from human liver Hansen, RG, Knop, JK	J Biol Chem	1970
5348606	Uridine diphosphate glucose pyrophosphorylase. II Hageman, E, Levine, S, Gillett, TA, Hansen, RG	J Biol Chem	1969