UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose

Stable Identifier
R-HSA-70286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic UDP-glucose pyrophosphorylase 2 (UGP2) catalyzes the reaction of UTP and glucose 1-phosphate to form UDP glucose and pyrophosphate (Knop and Hansen 1970; Duggleby et al. 1996). UGP2 is inferred to occur in the cell as a homooctamer from studies of its bovine homologue (Levine et al. 1969).

Literature References
PubMed ID Title Journal Year
5427280 Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization and properties of the enzyme from human liver

Knop, JK, Hansen, RG

J Biol Chem 1970
5348606 Uridine diphosphate glucose pyrophosphorylase. II

Levine, S, Gillett, TA, Hageman, E, Hansen, RG

J Biol Chem 1969
8631325 Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli.

Duggleby, RG, Chao, YC, Huang, JG, Peng, HL, Chang, HY

Eur J Biochem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UTP:glucose-1-phosphate uridylyltransferase activity of 8xUGP2 [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed