Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).
Lin, S, McLennan, AG, Ying, K, Wang, Z, Gu, S, Jin, H, Wu, C, Liu, W, Yuan, Y, Tang, R, Xie, Y, Mao, Y
Abolhassani, N, Iyama, T, Tsuchimoto, D, Sakumi, K, Ohno, M, Behmanesh, M, Nakabeppu, Y
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