Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).
Iyama, T, Ohno, M, Nakabeppu, Y, Sakumi, K, Abolhassani, N, Behmanesh, M, Tsuchimoto, D
Gu, S, Jin, H, Ying, K, Tang, R, Liu, W, Xie, Y, Yuan, Y, Mao, Y, McLennan, AG, Lin, S, Wu, C, Wang, Z
dITP diphosphatase activity of ITPA dimer [cytosol]
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