ITPA hydrolyses dITP to dIMP

Stable Identifier
R-HSA-2509838
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
dITP + H2O => dIMP + PPi
Locations in the PathwayBrowser
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Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).

Literature References
PubMed ID Title Journal Year
11278832 Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene

Lin, S, McLennan, AG, Ying, K, Wang, Z, Gu, S, Jin, H, Wu, C, Liu, W, Yuan, Y, Tang, R, Xie, Y, Mao, Y

J. Biol. Chem. 2001
20081199 NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Abolhassani, N, Iyama, T, Tsuchimoto, D, Sakumi, K, Ohno, M, Behmanesh, M, Nakabeppu, Y

Nucleic Acids Res. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dITP diphosphatase activity of ITPA dimer [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created