Reactome | ITPA hydrolyses dITP to dIMP

ITPA hydrolyses dITP to dIMP

Stable Identifier

R-HSA-2509838

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

dITP + H2O => dIMP + PPi

ReviewStatus

5/5

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Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20081199	NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals Iyama, T, Ohno, M, Nakabeppu, Y, Sakumi, K, Abolhassani, N, Behmanesh, M, Tsuchimoto, D	Nucleic Acids Res.	2010
11278832	Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene Gu, S, Jin, H, Ying, K, Tang, R, Liu, W, Xie, Y, Yuan, Y, Mao, Y, McLennan, AG, Lin, S, Wu, C, Wang, Z	J. Biol. Chem.	2001