QPRT transfers PRIB to QUIN to form NAMN

Stable Identifier
R-HSA-197268
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
A phospho-ribosyl group is added to quinolinate
ReviewStatus
5/5
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QPRT transfers PRIB to QUIN to form NAMN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The enzyme, nicotinate nucleotide pyrophosphorylase, is specific for quinolinate. Its activity is strictly dependent on Mg2+ ions being present. A phosphoribosyl group is transferred to quinolinate to form nicotinate D-ribonucleotide. This reaction represents another rate-limiting step of the pathway from tryptophan to NAD+.

Literature References
PubMed ID Title Journal Year
9473669 Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase

Shibata, K, Fukuoka, SI, Nyaruhucha, CM

Biochim Biophys Acta 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

nicotinate-nucleotide diphosphorylase (carboxylating) activity of QPRT [cytosol]

Physical Entity
QPRT [cytosol] (Homo sapiens)
Activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity (GO:0004514)
Orthologous Events
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-05-02)
Created
Jassal, B  (2007-05-02)
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