THG1L transfers GMP to 5' end of tRNA(His)

Stable Identifier
R-HSA-6782434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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THG1L (THG1) adds a guanosine triphosphate residue to the 5' end of tRNA(His), a 3'-5' addition that contrasts with the usual 5'-3' directionality of nucleotide polymerases (Hyde et al. 2010).

Literature References
PubMed ID Title Journal Year
21059936 tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases

Hyde, SJ, Eckenroth, BE, Smith, BA, Eberley, WA, Heintz, NH, Jackman, JE, DoubliƩ, S

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
nucleotidyltransferase activity of THG1L [cytosol]
Physical Entity
Activity
Authored
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