THG1L transfers GMP to 5' end of tRNA(His)

Stable Identifier
R-HSA-6782434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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THG1L transfers GMP to 5' end of tRNA(His)
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THG1L (THG1) adds a guanosine triphosphate residue to the 5' end of tRNA(His), a 3'-5' addition that contrasts with the usual 5'-3' directionality of nucleotide polymerases (Hyde et al. 2010).

Literature References
PubMed ID Title Journal Year
21059936 tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases

Hyde, SJ, Eberley, WA, Eckenroth, BE, Heintz, NH, Doublié, S, Jackman, JE, Smith, BA

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

nucleotidyltransferase activity of THG1L [cytosol]

Physical Entity
THG1L [cytosol] (Homo sapiens)
Activity
nucleotidyltransferase activity (GO:0016779)
Authored
May, B  (2015-06-07)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-08)
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