Reactome | Cyclisation of GTP to precursor Z

Cyclisation of GTP to precursor Z

Stable Identifier

R-HSA-947535

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GTP cyclizes in a reaction involving radicals of S-adenosylmethionine, catalyzed by the iron-sulfur cluster dimeric MOCS1. The intermediate result is called precursor Z (Hanzelmann et al, 2002; Hanzelmann et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
11891227	Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis Hänzelmann, P, Schwarz, G, Mendel, RR	J Biol Chem	2002
15180982	Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis Hänzelmann, P, Hernández, HL, Menzel, C, Garcia-Serres, R, Huynh, BH, Johnson, MK, Mendel, RR, Schindelin, H	J Biol Chem	2004