XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate

Stable Identifier
R-HSA-73792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
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XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
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Cytosolic GMP synthase (GMPS) catalyzes the reaction of xanthosine 5'-monophosphate (XMP), ATP, glutamine and water to form guanosine 5'-monophosphate (GMP), AMP, glutamate and pyrophosphate. GMPS is a monomer (Hirst et al. 1994; Nakamura and Lou 1995).

Literature References
PubMed ID Title Journal Year
8089153 Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA

Hirst, M, Haliday, E, Nakamura, J, Lou, L

J Biol Chem 1994
7706277 Biochemical characterization of human GMP synthetase

Nakamura, J, Lou, L

J Biol Chem 1995
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol]
Physical Entity
GMPS [cytosol]
Activity
GMP synthase (glutamine-hydrolyzing) activity (0003922)
Orthologous Events
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Danio rerio)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2004-02-23)
Created
Jassal, B  (2003-06-26)