glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate

Stable Identifier
R-HSA-379861
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Multifunctional EPRS (cytosolic glutamyl prolyl tRNA synthetase) catalyzes the reaction of glutamate, tRNA(Glu), and ATP to form Glu tRNA(Glu), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Pro) with proline. The enzyme is found in the cell as a component of the mutienzyme aminoacyl tRNA synthetase complex (Kaiser et al. 1994).

Literature References
PubMed ID Title Journal Year
8188258 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase

Knippers, R, Baack, M, Hu, B, Hameister, H, Schray, B, Becher, S, Eberhard, D, Kaiser, E

Genomics 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutamate-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]

Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Activity
glutamate-tRNA ligase activity (GO:0004818)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-06)
Cite Us!