glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate

Stable Identifier
R-HSA-379861
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
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Multifunctional EPRS (cytosolic glutamyl prolyl tRNA synthetase) catalyzes the reaction of glutamate, tRNA(Glu), and ATP to form Glu tRNA(Glu), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Pro) with proline. The enzyme is found in the cell as a component of the mutienzyme aminoacyl tRNA synthetase complex (Kaiser et al. 1994).

Literature References
PubMed ID Title Journal Year
8188258 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase

Kaiser, E, Hu, B, Becher, S, Eberhard, D, Schray, B, Baack, M, Hameister, H, Knippers, R

Genomics 1994
Participants
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Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glutamate-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol]
Activity
glutamate-tRNA ligase activity (0004818)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-06)
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