ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell

Stable Identifier
R-HSA-434382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.
Literature References
PubMed ID Title Journal Year
28193492 Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion

Stoker, SW, Ansari, IH, MacDonald, MJ, Fernandez, LA, Kendrick, MA, Ntambi, JM, Zitur, LJ, Longacre, MJ, O'Neill, LM

Arch. Biochem. Biophys. 2017
Participants
Input
Output
Participates
as an event of
Catalyst Activity

palmitoyl-CoA ligase activity of ACSL3,4 [mitochondrial outer membrane]

Physical Entity
ACSL3,4 [mitochondrial outer membrane] (Homo sapiens)
Activity
palmitoyl-CoA ligase activity (GO:0090433)
Orthologous Events
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Caenorhabditis elegans)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Danio rerio)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Gallus gallus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)
ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)
Cross References
Rhea
Authored
May, B  (2009-08-28)
Reviewed
D'Eustachio, P  (2018-12-22)
Created
May, B  (2009-08-28)
Cite Us!