H2SeO4 is converted to APSe by PAPSS1,2

Stable Identifier
R-HSA-2408525
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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H2SeO4 is converted to APSe by PAPSS1,2
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Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthases 1 and 2 (PAPSS1,2) (Venkatachalam et al. 1998, Xu et al. 2000) are involved in transforming adenosine triphosphate (ATP) and selenic acid (H2SeO4) into adenylylselenate (APSe) and diphosphate via its ATP sulphurylase domain. This reaction is inferred from the event in rat (Yu et al. 1989).

Literature References
PubMed ID Title Journal Year
2537056 Rat liver ATP-sulfurylase: purification, kinetic characterization, and interaction with arsenate, selenate, phosphate, and other inorganic oxyanions

Chen, LJ, Segel, IH, Yu, M, Martin, RL, Jain, S

Arch. Biochem. Biophys. 1989
9668121 Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains

Venkatachalam, KV, Akita, H, Strott, CA

J Biol Chem 1998
10679223 Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization

Xu, JP, Kim, UJ, Freimuth, RR, Mitchell, S, Moon, E, Otterness, DM, Wood, TC, Xu, ZH, Carlini, EJ, Weinshilboum, RM, Siciliano, MJ

Biochem. Biophys. Res. Commun. 2000
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Catalyst Activity

selenate adenylyltransferase (ATP) activity of PAPSS1,2 [cytosol]

Physical Entity
PAPSS1,2 [cytosol] (Homo sapiens)
Activity
selenate adenylyltransferase (ATP) activity (GO:0098616)
Inferred From
H2SeO4 is converted to APSe by PAPSS1,2 (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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