Reactome | GGPS1 hexamer transfers IPPP to GPP

GGPS1 hexamer transfers IPPP to GPP

Stable Identifier

R-HSA-9717830

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

isopentenyl diphosphate + (2E)-geranyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate, Another isopentenyl pyrophosphate is added to geranyl pyrophosphate

ReviewStatus

5/5

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Further condensation of an isopentenyl pyrophosphate (IPPP) with geranyl pyrophosphate (GPP) to form farnesyl pyrophosphate (FAPP) is catalyzed by the prenyltransferases FPP synthase and GGPP synthase (Ericsson et al. 1998; Kavanagh et al, 2006; Kuzuguchi et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9741684	Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression Ericsson, J, Greene, JM, Carter, KC, Shell, BK, Duan, DR, Florence, C, Edwards, PA	J Lipid Res	1998
16684881	The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Kavanagh, KL, Guo, K, Dunford, JE, Wu, X, Knapp, S, Ebetino, FH, Rogers, MJ, Russell, RG, Oppermann, U	Proc Natl Acad Sci U S A	2006
10026212	Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T, Morita, Y, Sagami, I, Sagami, H, Ogura, K	J Biol Chem	1999