Reactome | NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

Stable Identifier

R-HSA-2395869

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

8-oxo-dGTP + H2O => 8-oxo-dGMP + PPi (NUDT15)

ReviewStatus

5/5

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NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

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NUDT15 (MTH2) catalyzes the reaction of 8-oxo-dGTP and water to form 8-oxo-dGMP and PPi (pyrophosphate). Cai et al. (2003) first identified this activity in studies of the homologous mouse protein; the activity of the human NUDT15 protein has since been confirmed experimentally (Takagi et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22556419	Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2 Takagi, Y, Setoyama, D, Ito, R, Kamiya, H, Yamagata, Y, Sekiguchi, M	J. Biol. Chem.	2012
12767940	Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides Cai, JP, Ishibashi, T, Takagi, Y, Hayakawa, H, Sekiguchi, M	Biochem. Biophys. Res. Commun.	2003