NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

Stable Identifier
R-HSA-2395869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8-oxo-dGTP + H2O => 8-oxo-dGMP + PPi (NUDT15)
Locations in the PathwayBrowser
General
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NUDT15 (MTH2) catalyzes the reaction of 8-oxo-dGTP and water to form 8-oxo-dGMP and PPi (pyrophosphate). Cai et al. (2003) first identified this activity in studies of the homologous mouse protein; the activity of the human NUDT15 protein has since been confirmed experimentally (Takagi et al. 2012).

Literature References
PubMed ID Title Journal Year
12767940 Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides

Cai, JP, Ishibashi, T, Takagi, Y, Hayakawa, H, Sekiguchi, M

Biochem. Biophys. Res. Commun. 2003
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Setoyama, D, Ito, R, Kamiya, H, Yamagata, Y, Sekiguchi, M

J. Biol. Chem. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT15 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created