PCho and CTP are condensed to CDP-Cho by PCYT1 dimer

Stable Identifier
R-HSA-1483081
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
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At the endoplasmic reticulum (ER) membrane, active membrane-bound choline-phosphate cytidylyltransferase A (PCYT1A) or B (PCYT1B) homodimer condenses phosphocholine (PCho) and cytidine triphosphate (CTP) to produce CDP-choline (CDP-Cho) (Lykidis et al. 1998).
Literature References
PubMed ID Title Journal Year
9593753 Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase

Murti, KG, Jackowski, S, Lykidis, A

J Biol Chem 1998
Participants
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Output
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as an event of
Catalyst Activity

choline-phosphate cytidylyltransferase activity of PCYT1 dimer [endoplasmic reticulum membrane]

Physical Entity
PCYT1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
choline-phosphate cytidylyltransferase activity (GO:0004105)
Orthologous Events
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Gallus gallus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Rattus norvegicus)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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