Reactome | FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc

FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc

Stable Identifier

R-HSA-6787533

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

beta-L-fucose 1-phosphate + GTP + H(+) => GDP-beta-L-fucose + diphosphate

ReviewStatus

4/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        GDP-fucose biosynthesis (Homo sapiens)
        
        FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)

General

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SVG | | PPTX | SBGN

FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc

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Fucose-1-phosphate guanylyltransferase (FPGT) functions in a salvage pathway to reutilise L-fucose arising from the turnover of glycoproteins and glycolipids in the liver and other tissues. In the second step of the pathway, FPGT catalyses the transfer a guanylyl group from GTP to fucose-1-phosphate (Fu1P) to form GDP-L-fucose (GDP-Fuc), the high energy donor form used by fucosyltransferases in the Golgi to add fucose moieties to growing glycan chains (Quirk & Seley 2005).

Literature References