FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc

Stable Identifier
R-HSA-6787533
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Fucose-1-phosphate guanylyltransferase (FPGT) functions in a salvage pathway to reutilise L-fucose arising from the turnover of glycoproteins and glycolipids in the liver and other tissues. In the second step of the pathway, FPGT catalyses the transfer a guanylyl group from GTP to fucose-1-phosphate (Fu1P) to form GDP-L-fucose (GDP-Fuc), the high energy donor form used by fucosyltransferases in the Golgi to add fucose moieties to growing glycan chains (Quirk & Seley 2005).

Literature References
PubMed ID Title Journal Year
16086588 Substrate discrimination by the human GTP fucose pyrophosphorylase

Quirk, S, Seley, KL

Biochemistry 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fucose-1-phosphate guanylyltransferase activity of FPGT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created