FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc

Stable Identifier
R-HSA-6787533
Type
Reaction
Species
Homo sapiens
Compartment
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Fucose-1-phosphate guanylyltransferase (FPGT) functions in a salvage pathway to reutilise L-fucose arising from the turnover of glycoproteins and glycolipids in the liver and other tissues. In the second step of the pathway, FPGT catalyses the transfer a guanylyl group from GTP to fucose-1-phosphate (Fu1P) to form GDP-L-fucose (GDP-Fuc), the high energy donor form used by fucosyltransferases in the Golgi to add fucose moieties to growing glycan chains (Quirk & Seley 2005).

Literature References
PubMed ID Title Journal Year
16086588 Substrate discrimination by the human GTP fucose pyrophosphorylase

Seley, KL, Quirk, S

Biochemistry 2005
Participants
Participates
Catalyst Activity

fucose-1-phosphate guanylyltransferase activity of FPGT [cytosol]

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