orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate

Stable Identifier
R-GGA-419462
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
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The orotate phosphoribosyltransferase activity of dimeric UMPS (uridine monophosphate synthetase) catalyzes the reaction of orotate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to form orotidine 5'-monophosphate (OMP) and pyrophosphate. The chicken enzyme is known only as the product of a large-scale sequencing project to identify chicken mRNAs; all molecular details of the reaction are inferred from its human counterpart.
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Catalyst Activity

orotate phosphoribosyltransferase activity of UMPS dimer [cytosol]

Physical Entity
UMPS dimer [cytosol] (Gallus gallus)
Activity
orotate phosphoribosyltransferase activity (GO:0004588)
Inferred From
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
Authored
D'Eustachio, P  (2009-05-01)
Created
D'Eustachio, P  (2009-05-01)
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