UBA6 adenylates ubiquitin in the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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As inferred from the homologous UBA1, activation of ubiquitin by UBA6 (UBE1L1) proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA6, and adenylation of a second molecule of ubiquitin. In the first step, the adenylation module of UBA6 catalyzes the acyl-adenylation of the C-terminal glycine of ubiquitin (Jin et al. 2007, Pelzer et al. 2007, Groettrup et al. 2008).

Literature References
PubMed ID Title Journal Year
18353650 Activating the ubiquitin family: UBA6 challenges the field

Groettrup, M, Pelzer, C, Schmidtke, G, Hofmann, K

Trends Biochem. Sci. 2008
17597759 Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

Jin, J, Li, X, Gygi, SP, Harper, JW

Nature 2007
17580310 UBE1L2, a novel E1 enzyme specific for ubiquitin

Pelzer, C, Kassner, I, Matentzoglu, K, Singh, RK, Wollscheid, HP, Scheffner, M, Schmidtke, G, Groettrup, M

J. Biol. Chem. 2007
Catalyst Activity

ubiquitin activating enzyme activity of UBA6 [cytosol]

Inferred From
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