UBA6 adenylates ubiquitin in the cytosol

Stable Identifier
R-HSA-8865090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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UBA6 adenylates ubiquitin in the cytosol
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As inferred from the homologous UBA1, activation of ubiquitin by UBA6 (UBE1L1) proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA6, and adenylation of a second molecule of ubiquitin. In the first step, the adenylation module of UBA6 catalyzes the acyl-adenylation of the C-terminal glycine of ubiquitin (Jin et al. 2007, Pelzer et al. 2007, Groettrup et al. 2008).

Literature References
PubMed ID Title Journal Year
17597759 Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

Li, X, Gygi, SP, Jin, J, Harper, JW

Nature 2007
18353650 Activating the ubiquitin family: UBA6 challenges the field

Hofmann, K, Pelzer, C, Groettrup, M, Schmidtke, G

Trends Biochem. Sci. 2008
17580310 UBE1L2, a novel E1 enzyme specific for ubiquitin

Pelzer, C, Singh, RK, Groettrup, M, Scheffner, M, Matentzoglu, K, Schmidtke, G, Kassner, I, Wollscheid, HP

J. Biol. Chem. 2007
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Catalyst Activity

ubiquitin activating enzyme activity of UBA6 [cytosol]

Physical Entity
UBA6 [cytosol] (Homo sapiens)
Activity
ubiquitin activating enzyme activity (GO:0004839)
Inferred From
UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)
Authored
May, B  (2016-01-12)
Reviewed
Azevedo, JE  (2016-08-11)
Created
May, B  (2016-03-20)
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