OAS3 produces oligoadenylates

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Influenza A virus, Sindbis virus, Dengue virus, West Nile virus
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2'-5'-oligoadenylate synthetase 3 (OAS3) is a template-independent nucleotidyl transferase that, once activated by double-stranded RNA in the cytosol, produces second messenger molecules 5'-triphosphorylated 2′,5′-linked oligoadenylates (2-5A). OAS3 was reported to produce preferentially dimeric 2-5A (Rebouillat D et al. 1999). However recent reports showed that OAS3 is able to synthesize 2',5'-oligoadenylates of sufficient length (the triadenylate and longer) to activate RNase L and thus limit viral propagation (Ibsen MS et al. 2014; Li Y et al. 2016).

Literature References
PubMed ID Title Journal Year
25275129 The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation

Ibsen, MS, Gad, HH, Desprès, P, Boesen, T, Thavachelvam, K, Hartmann, R

J. Virol. 2014
26858407 Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

Silverman, RH, Dong, B, Wang, Y, Weiss, SR, Banerjee, S, Gaughan, C, Goldstein, SA, Li, Y

Proc. Natl. Acad. Sci. U.S.A. 2016
Catalyst Activity

2'-5'-oligoadenylate synthetase activity of OAS3:OAS3 ligand [cytosol]

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