OAS3 produces oligoadenylates

Stable Identifier
R-HSA-8985091
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Sindbis virus, Dengue virus, West Nile virus
Compartment
cytosol
ReviewStatus
5/5
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OAS3 produces oligoadenylates
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2'-5'-oligoadenylate synthetase 3 (OAS3) is a template-independent nucleotidyl transferase that, once activated by double-stranded RNA in the cytosol, produces second messenger molecules 5'-triphosphorylated 2′,5′-linked oligoadenylates (2-5A). OAS3 was reported to produce preferentially dimeric 2-5A (Rebouillat D et al. 1999). However recent reports showed that OAS3 is able to synthesize 2',5'-oligoadenylates of sufficient length (the triadenylate and longer) to activate RNase L and thus limit viral propagation (Ibsen MS et al. 2014; Li Y et al. 2016).
Literature References
PubMed ID Title Journal Year
25275129 The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation

Ibsen, MS, Gad, HH, Thavachelvam, K, Boesen, T, Desprès, P, Hartmann, R

J. Virol. 2014
26858407 Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

Li, Y, Banerjee, S, Wang, Y, Goldstein, SA, Dong, B, Gaughan, C, Silverman, RH, Weiss, SR

Proc. Natl. Acad. Sci. U.S.A. 2016
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Catalyst Activity

2'-5'-oligoadenylate synthetase activity of OAS3:OAS3 ligand [cytosol]

Physical Entity
OAS3:OAS3 ligand [cytosol] (Homo sapiens)
Activity
2'-5'-oligoadenylate synthetase activity (GO:0001730)
Authored
Shamovsky, V  (2017-03-27)
Reviewed
D'Eustachio, P  (2017-12-02)
Silverman, RH  (2018-07-31)
Created
Shamovsky, V  (2017-04-12)
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