K63polyUb-TRAF6 ubiquitinates TAK1

Stable Identifier
R-HSA-5607757
Type
Reaction [omitted]
Species
Homo sapiens
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TAK1-binding protein 2 (TAB2), or its homologue TAB3, binds preferentially to K63-linked polyubiquitin chains in TRAF6 and links TRAF6 (TNF receptor-associated factor 6) to TAK1 (Transforming growth factor beta-associated kinase 1). TRAF6 ubiquitinates TAK1 on K34 and K158 and this triggers conformational changes in TAK1 that lead to autophosphorylation and activation (Fan et al. 2010, Hamidi et al. 2011).

Literature References
PubMed ID Title Journal Year
20038579 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation

Fan, Y, Yu, Y, Shi, Y, Sun, W, Xie, M, Ge, N, Mao, R, Chang, A, Xu, G, Schneider, MD, Zhang, H, Fu, S, Qin, J, Yang, J

J. Biol. Chem. 2010
22069318 Polyubiquitination of transforming growth factor ? (TGF?)-associated kinase 1 mediates nuclear factor-?B activation in response to different inflammatory stimuli

Hamidi, A, von Bulow, V, Hamidi, R, Winssinger, N, Barluenga, S, Heldin, CH, Landström, M

J. Biol. Chem. 2012
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Catalyst Activity
Title
ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane]
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Orthologous Events
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