K63polyUb-TRAF6 ubiquitinates TAK1

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TAK1-binding protein 2 (TAB2), or its homologue TAB3, binds preferentially to K63-linked polyubiquitin chains in TRAF6 and links TRAF6 (TNF receptor-associated factor 6) to TAK1 (Transforming growth factor beta-associated kinase 1). TRAF6 ubiquitinates TAK1 on K34 and K158 and this triggers conformational changes in TAK1 that lead to autophosphorylation and activation (Fan et al. 2010, Hamidi et al. 2011).

Literature References
PubMed ID Title Journal Year
22069318 Polyubiquitination of transforming growth factor ? (TGF?)-associated kinase 1 mediates nuclear factor-?B activation in response to different inflammatory stimuli

Landström, M, Barluenga, S, von Bulow, V, Winssinger, N, Hamidi, R, Heldin, CH, Hamidi, A

J. Biol. Chem. 2012
20038579 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation

Xie, M, Fan, Y, Fu, S, Zhang, H, Shi, Y, Mao, R, Ge, N, Sun, W, Schneider, MD, Yang, J, Qin, J, Xu, G, Yu, Y, Chang, A

J. Biol. Chem. 2010
Catalyst Activity

ubiquitin-protein transferase activity of p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane]

Orthologous Events
Cite Us!