Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs

Stable Identifier
R-HSA-9833031
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
ReviewStatus
5/5
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The RNA-dependent RNA polymerase complex (RdRP) of the respiratory syncytial virus (RSV) possesses poly(A) tail synthesis activity and all RSV mRNA, but not genomic RNAs, are polyadenylated (Mason et al. 2004). The polyA tail is present in 1C (NS1) mRNA (Dickens et al. 1984, Collins and Wertz 1985, Mason et al. 2004), 1B (NS2) mRNA (Dickens et al. 1984, Venkatesan et al. 1983, Collins and Wertz 1985, Mason et al. 2004), N mRNA (Dickens et al. 1984, Venkatesan et al. 1983, Mason et al. 2004), P mRNA (Dickens et al. 1984, Venkatesan et al. 1983, Mason et al. 2004), M mRNA (Dickens et a. 1984, Venkatesan et al. 1983, Mason et al. 2004), SH mRNA (Dickens et al. 1984, Mason et al. 2004), G mRNA (Dickens et al. 1984, Mason et al. 2004), F mRNA (Dickens et al. 1984, Mason et al. 2004), M2 mRNA (Dickens et al. 1984, Mason et al. 2004), and L mRNA (Dickens et al. 1984, Collins et al. 1987, Fearns and Collins 1999, Mason et al. 2004). The polyadenylation signal in M mRNA is not conserved (Satake and Venkatesan 1984). The polyadenylation signal is part of the gene end (GE) signal found at the end of each of the ten RSV genes (Kuo et al. 1996).
Literature References
PubMed ID Title Journal Year
9847343 Model for polymerase access to the overlapped L gene of respiratory syncytial virus

Collins, PL, Fearns, R

J Virol 1999
6699948 Nucleotide sequence of the gene encoding respiratory syncytial virus matrix protein

Venkatesan, S, Satake, M

J Virol 1984
6572388 Construction and characterization of cDNA clones for four respiratory syncytial viral genes

Chanock, RM, Elango, N, Venkatesan, S

Proc Natl Acad Sci U S A 1983
2998021 Nucleotide sequences of the 1B and 1C nonstructural protein mRNAs of human respiratory syncytial virus

Wertz, GW, Collins, PL

Virology 1985
8794332 Effects of mutations in the gene-start and gene-end sequence motifs on transcription of monocistronic and dicistronic minigenomes of respiratory syncytial virus

Grosfeld, H, Hill, MG, Kuo, L, Collins, PL, Cristina, J

J Virol 1996
15356293 Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor

Gaudette, Y, Lagace, L, Mason, SW, Lawetz, C, Dô, F, Liuzzi, M, Simoneau, B, Scouten, E

Nucleic Acids Res 2004
2440043 Gene overlap and site-specific attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus

Buckler-White, AJ, Spriggs, MK, Johnson, PR, Olmsted, RA, Collins, PL

Proc Natl Acad Sci U S A 1987
6492254 Transcriptional mapping of human respiratory syncytial virus

Dickens, LE, Wertz, GW, Collins, PL

J Virol 1984
Participants
Participates
Catalyst Activity

poly(A) RNA polymerase activity of RSV m7G(5')pppGm-mRNAs:RdRP:p-M2-1 [cytosol]

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