IARS (cytosolic aspartyl tRNA synthetase) catalyzes the reaction of isoleucine, tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Shiba et al. 1994).
Shigesada, K, Schimmel, P, Suzuki, N, Namba, Y, Shiba, K, Noda, T
isoleucine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
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