Reactome | tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

Stable Identifier

R-HSA-2408526

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer

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The synthetic cycle of selenocysteine (Sec) synthesis starts with misacylation (serylation) of the cognate transfer RNA (tRNA) for Sec, tRNASec, with serine (Ser) by Serine--tRNA ligase (SARS) homodimer. The structural homology of tRNASec and tRNASer enables SARS to form Ser-tRNASec (Vincent et al. 1997, Amberg et al. 1996, Heckl et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9637248	Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure Heckl, M, Busch, K, Gross, HJ	FEBS Lett.	1998
9431993	Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase Vincent, C, Tarbouriech, N, Hartlein, M	Eur J Biochem	1997
8890909	Selenocysteine synthesis in mammalia: an identity switch from tRNA(Ser) to tRNA(Sec) Amberg, R, Mizutani, T, Wu, XQ, Gross, HJ	J. Mol. Biol.	1996

Participants

Input

Output

Participant Of

hasEvent

Selenocysteine synthesis

Catalyst Activity

Title

selenocysteine-tRNA ligase activity of SARS dimer [cytosol]

Physical Entity

SARS dimer [cytosol]

Activity

selenocysteine-tRNA ligase activity (0098619)

Authored

Williams, MG (2014-05-06)

Reviewed

Rush, MG (2015-08-30)

Created

Williams, MG (2012-07-17)