The synthetic cycle of selenocysteine (Sec) synthesis starts with misacylation (serylation) of the cognate transfer RNA (tRNA) for Sec, tRNASec, with serine (Ser) by Serine--tRNA ligase (SARS) homodimer. The structural homology of tRNASec and tRNASer enables SARS to form Ser-tRNASec (Vincent et al. 1997, Amberg et al. 1996, Heckl et al. 1998).
Hartlein, M, Vincent, C, Tarbouriech, N
Busch, K, Gross, HJ, Heckl, M
Amberg, R, Gross, HJ, Mizutani, T, Wu, XQ
selenocysteine-tRNA ligase activity of SARS dimer [cytosol]
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