Reactome | GPR161 promotes cAMP production in a G alpha(s)-dependent manner

GPR161 promotes cAMP production in a G alpha(s)-dependent manner

Stable Identifier

R-HSA-5610727

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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GPR161 promotes cAMP production in a G alpha(s)-dependent manner

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cAMP is generated by the action of adenylate cyclases (reviewed in Sassone-Corsi, 2012). GPR161 is an orphan GPCR that has recently been identified as a negative regulator of Hh signaling that acts by increasing cellular cAMP levels in the absence of ligand. Overexpression of GPR161 increases cellular cAMP levels in a manner that depends on the G alpha s subunit, and depletion of GPR161 results in aberrant Hh signaling and a decrease in the ratio of processed GLI3R (Mukhopadhyay et al, 2013). These data suggest that GPR161 negatively regulates GLI processing in the absence of Hh signal by modulating PKA activity through cAMP levels (Mukhopadhyay et al, 2013; reviewed in Mukhopadhyay and Rohatgi, 2014).

Literature References

PubMed ID	Title	Journal	Year
23209152	The cyclic AMP pathway Sassone-Corsi, P	Cold Spring Harb Perspect Biol	2012
23332756	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling Scales, SJ, Wen, X, Rangell, L, Jackson, PK, Loktev, A, Mukhopadhyay, S, Ratti, N	Cell	2013
24845016	G-protein-coupled receptors, Hedgehog signaling and primary cilia Rohatgi, R, Mukhopadhyay, S	Semin. Cell Dev. Biol.	2014