Molybdenum ion transfer onto molybdopterin

Stable Identifier
R-HSA-947531
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Gephyrin, which stabilizes receptors on neuronal membranes, also catalyzes the transfer of a molybdenum ion onto the cofactor. The mechanism was elucidated in plants but, as the pathway is highly conserved, human gephyrin can complement missing plant proteins. Doubts remain about the actual molybdenum donor, probably molybdate, and whether a copper ion is possibly bound and removed (Stallmeyer et al, 1999).

Literature References
PubMed ID Title Journal Year
9990024 The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells

Stallmeyer, B, Schwarz, G, Schulze, J, Nerlich, A, Reiss, J, Kirsch, J, Mendel, RR

Proc Natl Acad Sci U S A 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
molybdopterin molybdotransferase activity of 3xGPHN:3xMg2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
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