TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)

Stable Identifier
R-HSA-193766
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
TetraHCA + ATP + CoASH => 25(R) TetraHCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
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TetraHCA (25(R) 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate), coenzyme A, and ATP react to form the CoA conjugate of 25(R) TetraHCA, AMP, pyrophosphate and water. This cytosolic reaction is catalyzed by SLC27A5 (BACS). SLC27A2 (VLCS) also catalyzes this reaction; the relative contributions of the two enzymes to de novo bile acid synthesis in vivo are not certain (Mihalik et al. 2002).

Literature References
PubMed ID Title Journal Year
11980911 Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling

Mihalik, SJ, Steinberg, SJ, Pei, Z, Park, J, Kim, DG, Heinzer, AK, Dacremont, G, Wanders, RJ, Cuebas, DA, Smith, KD, Watkins, PA

J Biol Chem 2002
10479480 Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein

Steinberg, SJ, Wang, SJ, McGuinness, MC, Watkins, PA

Mol Genet Metab 1999
10749848 The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase

Steinberg, SJ, Mihalik, SJ, Kim, DG, Cuebas, DA, Watkins, PA

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain fatty acid-CoA ligase activity of SLC27A5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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