proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate

Stable Identifier
R-HSA-379865
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
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Multifunctional EPRS (cytosolic glutamyl-prolyl tRNA synthetase) catalyzes the reaction of proline, tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Glu) with glutamate. The enzyme is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaiser et al. 1994).

Literature References
PubMed ID Title Journal Year
8188258 The human EPRS locus (formerly the QARS locus): a gene encoding a class I and a class II aminoacyl-tRNA synthetase

Knippers, R, Baack, M, Hu, B, Hameister, H, Schray, B, Becher, S, Eberhard, D, Kaiser, E

Genomics 1994
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Catalyst Activity

proline-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]

Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Activity
proline-tRNA ligase activity (GO:0004827)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-06)
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