Multifunctional EPRS (cytosolic glutamyl-prolyl tRNA synthetase) catalyzes the reaction of proline, tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The same enzyme also catalyzes the charging of tRNA(Glu) with glutamate. The enzyme is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Kaiser et al. 1994).
Knippers, R, Baack, M, Hu, B, Hameister, H, Schray, B, Becher, S, Eberhard, D, Kaiser, E
proline-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
© 2022 Reactome