glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate

Stable Identifier
R-HSA-379982
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate
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QARS (cytosolic glutaminyl tRNA synthetase) catalyzes the reaction of glutamine, tRNA(Gln), and ATP to form Gln-tRNA(Gln), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both the cytosolic and mitochondrial QARS enzymes (Lamour et al. 1994).

Literature References
PubMed ID Title Journal Year
8078941 Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer

Lamour, V, Quevillon, S, Diriong, S, N'Guyen, VC, Lipinski, M, Mirande, M

Proc Natl Acad Sci U S A 1994
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Catalyst Activity
Catalyst Activity
Title
glutamine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]
Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol]
Activity
glutamine-tRNA ligase activity (0004819)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-06)