Soluble guanylate cyclase converts GTP to cGMP

Stable Identifier
R-HSA-392152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Soluble guanylate cyclase converts GTP to cGMP
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Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanylate cyclase activity of Guanylate cyclase:NO [cytosol]

Physical Entity
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Activity
guanylate cyclase activity (GO:0004383)
This event is regulated
Positively by
Regulator
Guanylate cyclase:CO [cytosol] (Homo sapiens)
Regulator
NO:sGC:sGC stimulators [cytosol] (Homo sapiens)
Regulator
NO [cytosol]
Regulator
NO:sGC:cinaciguat [cytosol] (Homo sapiens)
Inferred From
Soluble guanylate cyclase converts GTP to cGMP (Rattus norvegicus)
Cross References
Rhea
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-02-27)
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