Soluble guanylate cyclase converts GTP to cGMP

Stable Identifier
R-HSA-392152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Soluble guanylate cyclase converts GTP to cGMP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanylate cyclase activity of Guanylate cyclase:NO [cytosol]

Physical Entity
Guanylate cyclase:NO [cytosol] (Homo sapiens)
Activity
guanylate cyclase activity (GO:0004383)
This event is regulated
Positively by
Regulator
Guanylate cyclase:CO [cytosol] (Homo sapiens)
Regulator
NO:sGC:sGC stimulators [cytosol] (Homo sapiens)
Regulator
NO [cytosol]
Regulator
NO:sGC:cinaciguat [cytosol] (Homo sapiens)
Inferred From
Soluble guanylate cyclase converts GTP to cGMP (Rattus norvegicus)
Cross References
Rhea
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-02-27)
Cite Us!