FadD26, FadD28 transfer adenylyl group to a LCFA

Stable Identifier
R-MTU-9635480
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
Synonyms
2 LCFA + 2 ATP + 2 H+ => 2 LCFA adenylate ester + 2 PPi
ReviewStatus
5/5
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FadD26, FadD28 transfer adenylyl group to a LCFA
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Mtb FadD proteins (FadD26 and FadD28) are a class of long-chain fatty acyl-AMP ligases (FAALs) that catalyze the transfer of an adenylyl group from ATP to long-chain fatty acids (LCFA) to form LCFA adenylate esters (LCFA adenylate ester). This transfer has the effect of activating fatty acids for further chain extension (Trivedi et al. 2004).
Literature References
PubMed ID Title Journal Year
15042094 Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria

Trivedi, OA, Arora, P, Sridharan, V, Tickoo, R, Mohanty, D, Gokhale, RS

Nature 2004
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Catalyst Activity

adenylyltransferase activity of FadD26, FadD28 [cytosol]

Physical Entity
FadD26, FadD28 [cytosol] (Mycobacterium tuberculosis)
Activity
adenylyltransferase activity (GO:0070566)
Authored
Pardo, AM  (2019-02-13)
Koile, I  (2019-02-13)
Reviewed
Stephan, R  (2019-02-13)
Created
Pardo, AM  (2019-02-05)
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