ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate

Stable Identifier
R-GGA-187586
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Cytosolic argininosuccinate synthetase (ASS1) catalyzes the reaction of ATP, aspartate, and citrulline to form argininosuccinate, AMP, and pyrophosphate. The enzyme has been partially purified from kidney tissue (it was undetectable in liver) and biochemically characterized. The ASS1 gene has not been directly studied but rather has been identified computationally in the ENSEMBL chicken gene set as an open reading frame capable of encoding a protein similar to human ASS1.

Literature References
PubMed ID Title Journal Year
14061730 A study of ornithine, citrulline and arginine synthesis in growing chicks

Tamir, H, Ratner, S

Arch Biochem Biophys 1963
14064979 Enzymes of arginine metabolism in chicks

Tamir, H, Ratner, S

Arch Biochem Biophys 1963
Participants
Participates
Catalyst Activity

argininosuccinate synthase activity of ASS1 [cytosol]

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