APRT catalyzes the conversion of adenine to AMP

Stable Identifier
R-HSA-74213
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Adenine + PRPP => AMP + PPi
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Cytosolic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979; Silva et al. 2008).

Literature References
PubMed ID Title Journal Year
18399692 Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism

Thiemann, OH, Silva, CH, Iulek, J, Silva, M

J Biomol Struct Dyn 2008
457664 Human adenine phosphoribosyltransferase. Affinity purification, subunit structure, amino acid composition, and peptide mapping.

Holden, JA, Meredith, GS, Kelley, WN

J Biol Chem 1979
Participants
Participates
Catalyst Activity

adenine phosphoribosyltransferase activity of APRT dimer [cytosol]

Orthologous Events
Cross References
Rhea
Created
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