Reactome | APRT catalyzes the conversion of adenine to AMP

APRT catalyzes the conversion of adenine to AMP

Stable Identifier

R-HSA-74213

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Adenine + PRPP => AMP + PPi

ReviewStatus

5/5

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APRT catalyzes the conversion of adenine to AMP

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Cytosolic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979; Silva et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18399692	Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism Silva, CH, Silva, M, Iulek, J, Thiemann, OH	J Biomol Struct Dyn	2008
457664	Human adenine phosphoribosyltransferase. Affinity purification, subunit structure, amino acid composition, and peptide mapping. Holden, JA, Meredith, GS, Kelley, WN	J Biol Chem	1979