Adenine + PRPP => AMP + PPi

Stable Identifier
R-HSA-74213
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Adenine + PRPP => AMP + PPi
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Cytosolic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979).

Literature References
PubMed ID Title Journal Year
457664 Human adenine phosphoribosyltransferase. Affinity purification, subunit structure, amino acid composition, and peptide mapping.

Holden, JA, Meredith, GS, Kelley, WN

J Biol Chem 1979
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
adenine phosphoribosyltransferase activity of APRT dimer [cytosol]
Physical Entity
APRT dimer [cytosol]
Activity
adenine phosphoribosyltransferase activity (0003999)
Orthologous Events
Adenine + PRPP => AMP + PPi (Bos taurus)
Adenine + PRPP => AMP + PPi (Caenorhabditis elegans)
Adenine + PRPP => AMP + PPi (Canis familiaris)
Adenine + PRPP => AMP + PPi (Danio rerio)
Adenine + PRPP => AMP + PPi (Drosophila melanogaster)
Adenine + PRPP => AMP + PPi (Gallus gallus)
Adenine + PRPP => AMP + PPi (Mus musculus)
Adenine + PRPP => AMP + PPi (Rattus norvegicus)
Adenine + PRPP => AMP + PPi (Saccharomyces cerevisiae)
Adenine + PRPP => AMP + PPi (Schizosaccharomyces pombe)
Adenine + PRPP => AMP + PPi (Sus scrofa)
Adenine + PRPP => AMP + PPi (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-07-17)