Anthrax EF catalyzes the conversion of ATP to cAMP

Stable Identifier
R-HSA-5211224
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
Synonyms
ATP => cAMP + PPi (EF)
Locations in the PathwayBrowser
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EF (edema factor), transported to the cytosol of the target cell, catalyzes the synthesis of cAMP from ATP, in a reaction that requires target cell calmodulin (Leppla 1984; Labruyere et al. 1990).

Literature References
PubMed ID Title Journal Year
6328915 Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells

Leppla, SH

Adv Cyclic Nucleotide Protein Phosphorylation Res 1984
2114169 Characterization of ATP and calmodulin-binding properties of a truncated form of Bacillus anthracis adenylate cyclase

Labruyère, E, Mock, M, Ladant, D, Michelson, S, Gilles, AM, Laoide, B, Bârzu, O

Biochemistry 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenylate cyclase activity of EF [cytosol]
Physical Entity
Activity
This event is regulated
Disease
Name Identifier Synonyms
anthrax disease 7427
Cross References
Rhea
Authored
Reviewed
Created
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