Anthrax cya catalyzes the conversion of ATP to cAMP

Stable Identifier
R-HSA-5211224
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
Synonyms
ATP => cAMP + PPi (EF)
ReviewStatus
5/5
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Anthrax cya catalyzes the conversion of ATP to cAMP
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cya (EF, edema factor), transported to the cytosol of the target cell, catalyzes the synthesis of cAMP from ATP, in a reaction that requires target cell calmodulin (Leppla 1984; Labruyere et al. 1990).
Literature References
PubMed ID Title Journal Year
2114169 Characterization of ATP and calmodulin-binding properties of a truncated form of Bacillus anthracis adenylate cyclase

Laoide, B, Mock, M, Michelson, S, Bârzu, O, Labruyère, E, Gilles, AM, Ladant, D

Biochemistry 1990
6328915 Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells

Leppla, SH

Adv Cyclic Nucleotide Protein Phosphorylation Res 1984
Participants
Input
Output
Participates
as an event of
Catalyst Activity

adenylate cyclase activity of cya [cytosol]

Physical Entity
cya [cytosol] (Bacillus anthracis)
Activity
adenylate cyclase activity (GO:0004016)
This event is regulated
Requirements
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
Rhea
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-08)
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