Reactome | FDPS dimer transfers IPPP to GPP

FDPS dimer transfers IPPP to GPP

Stable Identifier

R-HSA-191303

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Another isopentenyl pyrophosphate is added to geranyl pyrophosphate

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Further condensation of an isopentenyl pyrophosphate (IPPP) with geranyl pyrophosphate (GPP) to form farnesyl pyrophosphate (FAPP) is catalyzed by the prenyltransferases FPP synthase and GGPP synthase (Kavanagh et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
9741684	Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression Edwards, PA, Shell, BK, Greene, JM, Ericsson, J, Florence, C, Carter, KC, Duan, DR	J Lipid Res	1998
16684881	The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Knapp, S, Russell, RG, Guo, K, Oppermann, U, Ebetino, FH, Kavanagh, KL, Dunford, JE, Rogers, MJ, Wu, X	Proc Natl Acad Sci U S A	2006
10026212	Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Sagami, I, Kuzuguchi, T, Morita, Y, Sagami, H, Ogura, K	J Biol Chem	1999