Reactome | FDPS dimer transfers IPPP to GPP

FDPS dimer transfers IPPP to GPP

Stable Identifier

R-HSA-191303

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Another isopentenyl pyrophosphate is added to geranyl pyrophosphate

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Further condensation of an isopentenyl pyrophosphate (IPPP) with geranyl pyrophosphate (GPP) to form farnesyl pyrophosphate (FAPP) is catalyzed by the prenyltransferases FPP synthase and GGPP synthase (Kavanagh et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16684881	The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Kavanagh, KL, Guo, K, Dunford, JE, Wu, X, Knapp, S, Ebetino, FH, Rogers, MJ, Russell, RG, Oppermann, U	Proc Natl Acad Sci U S A	2006
9741684	Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression Ericsson, J, Greene, JM, Carter, KC, Shell, BK, Duan, DR, Florence, C, Edwards, PA	J Lipid Res	1998
10026212	Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T, Morita, Y, Sagami, I, Sagami, H, Ogura, K	J Biol Chem	1999