Another isopentenyl pyrophosphate is added to geranyl pyrophosphate

Stable Identifier
R-HSA-191303
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Further condensation of an isopentenyl pyrophosphate with geranyl pyrophosphate to form farnesyl pyrophosphate is catalyzed by the prenyltransferases FPP synthase and GGPP synthase. (Kavanagh et al, 2006)

Literature References
PubMed ID Title Journal Year
16684881 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

Kavanagh, KL, Guo, K, Dunford, JE, Wu, X, Knapp, S, Ebetino, FH, Rogers, MJ, Russell, RG, Oppermann, U

Proc Natl Acad Sci U S A 2006
9741684 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression

Ericsson, J, Greene, JM, Carter, KC, Shell, BK, Duan, DR, Florence, C, Edwards, PA

J Lipid Res 1998
10026212 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.

Kuzuguchi, T, Morita, Y, Sagami, I, Sagami, H, Ogura, K

J Biol Chem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
geranyltranstransferase activity of FDPS,GGPS1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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