tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
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YARS (cytosolic tyrosyl tRNA synthetase) catalyzes the reaction of tyrosine, tRNA(Tyr), and ATP to form Tyr tRNA(Tyr), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Yang et al. 2003). Mutations in the YARS gene are associated with dominant-intermediate Charcot-Marie-Tooth disease – a form of peripheral neuropathy characterized by axon and Schwann cell dysfunction (Jordanova et al. 2006).

Literature References
PubMed ID Title Journal Year
16429158 Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy

Meerschaert, K, Guergueltcheva, V, Thomas, FP, Robberecht, W, Gettemans, J, Tournev, I, Rao, CV, Gondim, FA, D'Hooghe, M, Dewil, M, Dierick, I, Jordanova, A, Van Dijck, P, De Vriendt, E, De Jonghe, P, Thevelein, JM, Van Gerwen, V, Jacobs, A, Kremensky, I, Van Den Bosch, L, Callaerts, P, Timmerman, V, Timmermans, JP, Irobi, J

Nat Genet 2006
14671330 Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains

Yang, XL, Schimmel, P, McRee, DE, Ribas de Pouplana, L, Skene, RJ, Otero, FJ

Proc Natl Acad Sci U S A 2003
Catalyst Activity

tyrosine-tRNA ligase activity of YARS dimer [cytosol]

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