Transfer of Ub from E2 to substrate and release of E2

Stable Identifier
R-HSA-983140
Type
Reaction
Species
Homo sapiens
Compartment
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Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).

Literature References
PubMed ID Title Journal Year
12646216 U-box proteins as a new family of ubiquitin ligases

Hatakeyama, S, Nakayama, KI

Biochem Biophys Res Commun 2003
16954532 A novel family of membrane-bound E3 ubiquitin ligases

Goto, E, Hotta, H, Ishido, S, Mito, M, Uematsu, M, Aoki, M, Ohmura-Hoshino, M, Matsuki, Y

J Biochem 2006
19489725 RING domain E3 ubiquitin ligases

Deshaies, RJ, Joazeiro, CA

Annu Rev Biochem 2009
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of E3 ligases in proteasomal degradation [cytosol]

Orthologous Events
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