Reactome | Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL

Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL

Stable Identifier

R-HSA-4419986

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol, cytoplasmic side of endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of Dolichyl-phosphate (Homo sapiens)
        
        Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)

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Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL

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In mammals, polyprenol pyrophosphate (pPPP) requires dephosphorylation to polyprenol (pPNOL), which can then be reduced. Although pPPP phosphatase activity has been reported (Wolf et al. 1991), no pPPP phosphatase enzyme has yet been identified (Schenk et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11425794	The ins(ide) and out(side) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulum Schenk, B, Waechter, CJ, Fernandez, F	Glycobiology	2001
1668143	Golgi-enriched membrane fractions from rat brain and liver contain long-chain polyisoprenyl pyrophosphate phosphatase activity Rush, JS, Wolf, MJ, Waechter, CJ	Glycobiology	1991

Participants

Input

Output

Participates

as an event of

Synthesis of Dolichyl-phosphate (Homo sapiens)

Catalyst Activity

phosphatase activity of pPPP phosphatase [endoplasmic reticulum membrane]

Physical Entity

pPPP phosphatase [endoplasmic reticulum membrane] (Homo sapiens)

Activity

phosphatase activity (GO:0016791)

Authored

Jassal, B (2013-08-29)

Reviewed

D'Eustachio, P (2013-10-29)

Created

Jassal, B (2013-08-29)

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