Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL

Stable Identifier
R-HSA-4419986
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol, cytoplasmic side of endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mammals, polyprenol pyrophosphate (pPPP) requires dephosphorylation to polyprenol (pPNOL), which can then be reduced. Although pPPP phosphatase activity has been reported (Wolf et al. 1991), no human enzyme with this activity has yet been identified (Schenk et al. 2001). A budding yeast enzyme capable of hydrolyzing pPPP to pPNOL has been described (Faulkner et al. 1999) and two orthologous human proteins, PLPP4 and PLPP5, have been identified. These orthologs, however, have not been shown to have pyrophosphatase activity (Takeuchi et al. 2007) and thus are not annotated as enablers of this reaction.
Literature References
PubMed ID Title Journal Year
11425794 The ins(ide) and out(side) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulum

Schenk, B, Fernandez, F, Waechter, CJ

Glycobiology 2001
10329682 The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae

Faulkner, A, Chen, X, Rush, J, Horazdovsky, B, Waechter, CJ, Carman, GM, Sternweis, PC

J Biol Chem 1999
1668143 Golgi-enriched membrane fractions from rat brain and liver contain long-chain polyisoprenyl pyrophosphate phosphatase activity

Wolf, MJ, Rush, JS, Waechter, CJ

Glycobiology 1991
17590538 Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase

Takeuchi, M, Harigai, M, Momohara, S, Ball, E, Abe, J, Furuichi, K, Kamatani, N

Gene 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatase activity of pPPP phosphatase [endoplasmic reticulum membrane]

Physical Entity
pPPP phosphatase [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phosphatase activity (GO:0016791)
Authored
Jassal, B  (2013-08-29)
Reviewed
D'Eustachio, P  (2013-10-29)
Created
Jassal, B  (2013-08-29)
Cite Us!