Reactome | Mannose-1-phosphate converted to GDP-Mannose

Mannose-1-phosphate converted to GDP-Mannose

Stable Identifier

R-HSA-446221

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of GDP-mannose (Homo sapiens)
        
        Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)

General

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Mannose-1-phosphate converted to GDP-Mannose

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Mannose 1-phosphate is converted to GDP-Mannose by mannose-1-phosphate guanyltransferase alpha and beta forms (GMPPA/B). This enzyme had originally been characterized from rat and bovine sources (Verachtert H et al, 1966) and more recently from pig (Ning B and Elbein AD, 2000).

Literature References

PubMed ID	Title	Journal	Year
11082198	Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins Elbein, AD, Ning, B	Eur J Biochem	2000
5946626	Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues Verachtert, H, Hansen, RG, Rodriguez, P, Bass, ST	J Biol Chem	1966

Participants

Input

Output

Participates

as an event of

Synthesis of GDP-mannose (Homo sapiens)

Catalyst Activity

mannose-1-phosphate guanylyltransferase activity of GMPPA/B [cytosol]

Physical Entity

GMPPA/B [cytosol] (Homo sapiens)

Activity

mannose-1-phosphate guanylyltransferase activity (GO:0004475)

Inferred From

Mannose-1-phosphate converted to GDP-Mannose (Rattus norvegicus)

Authored

Dall'Olio, GM (2009-11-10)

Reviewed

Gagneux, P (2010-04-16)

Created

Jassal, B (2009-11-10)

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