Reactome | Mannose-1-phosphate converted to GDP-Mannose

Mannose-1-phosphate converted to GDP-Mannose

Stable Identifier

R-HSA-446221

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of GDP-mannose (Homo sapiens)
        
        Mannose-1-phosphate converted to GDP-Mannose (Homo sapiens)

General

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Mannose-1-phosphate converted to GDP-Mannose

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Mannose 1-phosphate is converted to GDP-Mannose by mannose-1-phosphate guanyltransferase alpha and beta forms (GMPPA/B). This enzyme had originally been characterized from rat and bovine sources (Verachtert H et al, 1966) and more recently from pig (Ning B and Elbein AD, 2000).

Literature References

PubMed ID	Title	Journal	Year
5946626	Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues Verachtert, H, Rodriguez, P, Bass, ST, Hansen, RG	J Biol Chem	1966
11082198	Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins Ning, B, Elbein, AD	Eur J Biochem	2000

Participants

Input

Output

Participant Of

hasEvent

Synthesis of GDP-mannose

Catalyst Activity

Title

mannose-1-phosphate guanylyltransferase activity of GMPPA/B [cytosol]

Physical Entity

GMPPA/B [cytosol]

Activity

mannose-1-phosphate guanylyltransferase activity (0004475)

Inferred From

Mannose-1-phosphate converted to GDP-Mannose (Rattus norvegicus)

Authored

Dall'Olio, GM (2009-11-10)

Reviewed

Gagneux, P (2010-04-16)

Created

Jassal, B (2009-11-10)