PA is converted to CDP-DAG by CDS1

Stable Identifier
R-HSA-1483121
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidate cytidylyltransferase 1 (CDS1) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesize cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).

Literature References
PubMed ID Title Journal Year
3718705 Participation of the microsomal CDP-diglycerides in the mitochondrial biosynthesis of phosphatidylglycerol

Stuhne-Sekalec, L, Chudzik, J, Stanacev, NZ

Biochem Cell Biol 1986
9407135 The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content

Lykidis, A, Jackson, PD, Rock, CO, Jackowski, S

J Biol Chem 1997
Participants
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hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidate cytidylyltransferase activity of CDS1:Mg2+ [endoplasmic reticulum membrane]
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Activity
Orthologous Events
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Created