FNTA:FNTB transfers FARN to GNGT1

Stable Identifier
R-HSA-2530501
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Farnesyltransferase complex farnesylates the gamma subunit of transducin
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Prenylation is the process of post-translational addition of hydrophobic groups to proteins and is thought to help anchor proteins to cellular membranes. Farnesylation is a type of prenylation, where a farnesyl group (donated from farnesyl diphosphate, FPP) is added to a cysteine residue on a protein. The enzyme mediating this transfer is farnesyltransferase (FNT). FNT is a heterodimer comprising an alpha subunit (common to another prenylating enzyme called geranylgeranyltransferase, GGT) and a unique beta subunit (Long et al. 2001, Bell et al. 2002, deSolms et al. 2003). This complex recognises the CAAX box (C is the cysteine, A is any aliphatic amino acid, and X determines which enzyme acts on the protein) at the C-terminus of the target protein, in this case, the gamma subunit of transducin (GNG1) (Omer at al. 1993).

Literature References
PubMed ID Title Journal Year
12825937 Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

deSolms, SJ, Ciccarone, TM, MacTough, SC, Shaw, AW, Buser, CA, Ellis-Hutchings, M, Fernandes, C, Hamilton, KA, Huber, HE, Kohl, NE, Lobell, RB, Robinson, RG, Tsou, NN, Walsh, ES, Graham, SL, Beese, LS, Taylor, JS

J. Med. Chem. 2003
12036349 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency

Bell, IM, Gallicchio, SN, Abrams, M, Beese, LS, Beshore, DC, Bhimnathwala, H, Bogusky, MJ, Buser, CA, Culberson, JC, Davide, J, Ellis-Hutchings, M, Fernandes, C, Gibbs, JB, Graham, SL, Hamilton, KA, Hartman, GD, Heimbrook, DC, Homnick, CF, Huber, HE, Huff, JR, Kassahun, K, Koblan, KS, Kohl, NE, Lobell, RB, Lynch, JJ, Robinson, R, Rodrigues, AD, Taylor, JS, Walsh, ES, Williams, TM, Zartman, CB

J. Med. Chem. 2002
8494894 Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Omer, CA, Kral, AM, Diehl, RE, Prendergast, GC, Powers, S, Allen, CM, Gibbs, JB, Kohl, NE

Biochemistry 1993
11687658 The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

Long, SB, Hancock, PJ, Kral, AM, Hellinga, HW, Beese, LS

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein farnesyltransferase activity of FNTA:FNTB [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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