Defective RpoB in Mtb RNAP transcribes RNA polyanion

Stable Identifier
R-HSA-9697084
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Defective RpoB in Mtb RNAP transcribes RNA polyanion
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Mutations in several regions of bacterial RNA polymerase (RNAP) subunit rpoB disable binding of rifampicin, and recover enzymatic activity (Jin & Gross 1988, Telenti et al. 1993). The most clinically prevalent mutation associated with rifamycin resistance is S456L which accounts for 40-75% of all rifamycin resistant mutants (Stefan et al. 2018).
Literature References
PubMed ID Title Journal Year
3050121 Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance

Jin, DJ, Gross, CA

J. Mol. Biol. 1988
8095569 Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis

Marchesi, F, Imboden, P, Telenti, A, Matter, L, Colston, MJ, Cole, S, Schopfer, K, Bodmer, T, Lowrie, D

Lancet 1993
29661864 Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit

Stefan, MA, Garcia, GA, Ugur, FS

Antimicrob. Agents Chemother. 2018
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Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of mutant RNAP [cytosol]

Physical Entity
mutant RNAP [cytosol] (Mycobacterium tuberculosis)
Activity
DNA-directed 5'-3' RNA polymerase activity (GO:0003899)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-03-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Jassal, B  (2020-08-05)
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