tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate

Stable Identifier
Reaction [transition]
Homo sapiens
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WARS (cytosolic tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bange et al. 1992; Rubin et al. 1991; Yu et al. 2004).

Literature References
PubMed ID Title Journal Year
1373391 An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase

Bottger, EC, Flohr, T, Buwitt, U, Bange, FC

FEBS Lett 1992
1761529 Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts

Anderson, SL, Rubin, BY, Powell, RJ, Tate, WP, Xing, L

J Biol Chem 1991
14660560 Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity

Shen, N, Ding, J, Liu, Y, Xu, X, Arnold, E, Jia, J, Xu, F, Jin, Y, Yu, Y

J Biol Chem 2004
Catalyst Activity

tryptophan-tRNA ligase activity of WARS dimer [cytosol]

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