tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate

Stable Identifier
R-HSA-379977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
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WARS (cytosolic tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bange et al. 1992; Rubin et al. 1991; Yu et al. 2004).
Literature References
PubMed ID Title Journal Year
1373391 An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase

Bottger, EC, Flohr, T, Buwitt, U, Bange, FC

FEBS Lett 1992
1761529 Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts

Anderson, SL, Rubin, BY, Powell, RJ, Tate, WP, Xing, L

J Biol Chem 1991
14660560 Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity

Shen, N, Ding, J, Liu, Y, Xu, X, Arnold, E, Jia, J, Xu, F, Jin, Y, Yu, Y

J Biol Chem 2004
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Catalyst Activity

tryptophan-tRNA ligase activity of WARS dimer [cytosol]

Physical Entity
WARS dimer [cytosol] (Homo sapiens)
Activity
tryptophan-tRNA ligase activity (GO:0004830)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-07)
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