tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate

Stable Identifier
R-HSA-379977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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WARS (cytosolic tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bange et al. 1992; Rubin et al. 1991; Yu et al. 2004).

Literature References
PubMed ID Title Journal Year
1761529 Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts

Rubin, BY, Anderson, SL, Xing, L, Powell, RJ, Tate, WP

J Biol Chem 1991
1373391 An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase

Bange, FC, Flohr, T, Buwitt, U, Bottger, EC

FEBS Lett 1992
14660560 Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity

Yu, Y, Liu, Y, Shen, N, Xu, X, Xu, F, Jia, J, Jin, Y, Arnold, E, Ding, J

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
tryptophan-tRNA ligase activity of WARS dimer [cytosol]
Physical Entity
Activity
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