lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate

Stable Identifier
R-HSA-380008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
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KARS (cytosolic lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).

Literature References
PubMed ID Title Journal Year
9278442 Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant

Schimmel, P, Stello, T, Motegi, H, Shiba, K, Musier-Forsyth, K, Noda, T

J Biol Chem 1997
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Catalyst Activity

lysine-tRNA ligase activity of aminoacyl-tRNA synthetase multienzyme complex [cytosol]

Physical Entity
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
Activity
lysine-tRNA ligase activity (GO:0004824)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-07)
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