Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
Hatakeyama, S, Nakayama, KI
Goto, E, Hotta, H, Ishido, S, Mito, M, Uematsu, M, Aoki, M, Ohmura-Hoshino, M, Matsuki, Y
Deshaies, RJ, Joazeiro, CA
Rodrigo-Brenni, MC, Matyskiela, ME, Morgan, DO
ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol]
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