Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
Ohmura-Hoshino, M, Goto, E, Matsuki, Y, Aoki, M, Mito, M, Uematsu, M, Hotta, H, Ishido, S
Hatakeyama, S, Nakayama, KI
Deshaies, RJ, Joazeiro, CA
Matyskiela, ME, Rodrigo-Brenni, MC, Morgan, DO
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