Dephosphorylation of phospho-Cdh1

Stable Identifier
R-HSA-174124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation by mitotic kinases is believed to alter the conformation of Cdh1 preventing it from associating with the APC/C. Cdc14 is thought to contribute to the dephosphorylation of Cdh1 in late mitosis. Dephosphorylated Cdh1 then associates with and activates the APC/C.

Literature References
PubMed ID Title Journal Year
11598127 Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a

Bembenek, J, Yu, H

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of phospho-Cdh1 phosphatase [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created